ROLE OF VITAMIN K IN COAGULATION

vitamin k, a group of lipophilic and hydrophobic vitamin produced by bacteria inhabiting the large intestine, is necessary to form clotting factor II ,VII, IX, X and protein C as inactive precursors (zymogens) in the liver. although vitamin k is not involved in actual clot formation, of is required for the post translational carboxylation  ( in the ER of the hepatocytes of glutamic acid residues of the proteins necessary for blood coagulation.

People suffering from slow absorption of lipids as a consequence of vitamin K deficiency experience impaired coagulation function, excessive bleeding and hemorrhage. Those with vitamin K deficiency produce alternate protein that vitamin K antagonists are necessary anticoagulants which competes with vitamin K for the liver carboxylase which is responsible for putting on the extra carboxyl group.

the general name for this class of compounds is the coumarins, and coumadin and warfarin are common example. warfarin is used in medicine for those at high risk of thromboembolism in order to prevent coagulation cascade by reducing vitamin K-dependent synthesis of coagulation factor. warfarin's effect can be reduced by ingesting more vitamin K to reactivate the coagulation factor synthesis pathways.