Regulation of chromatin condensation
Regulation of chromatin condensation Chromatin condensation is regulated by several mechanisms. 1. Histone modification Histones can undergo: Acetylation Methylation Phosphorylation Ubiquitination 2. Histone acetylation Histone acetylation generally reduces interaction between histones and DNA and promotes a more open chromatin structure. 3. DNA methylation DNA methylation, particularly at CpG regions, is generally associated with transcriptional repression and condensed chromatin. 4. Chromatin-remodelling complexes ATP-dependent complexes reposition or remove nucleosomes, changing DNA accessibility. 5. Histone H1 H1 contributes to higher-order chromatin organization and compaction. Thus, chromatin condensation controls the accessibility of genes to transcription machinery.
